OMG…..and it’s only Monday

We just got a call from the pediatricians office. Apparently Gavin’s blood work came back from the gastro. Now we have another problem. His immunogloban (spelling?) G and M are very low.

We were told to call Akron Children’s Hospital and get in to see the allergist. What the heck does this mean? We can’t seem to find anything online about this. We called the allergist and she wants him in on Wednesday morning.

Fan-freakin-tastic, another rushed appointment. Remember what I said the other day about we’re used to always having the other shoe drop? This is exactly what I mean. We had nothing going on and that was nice for a change. However, the powers that be just don’t seem want us to have a break.

WTF……it’s only Monday and now we have added at least 2 more appointments for the week, one being in Akron.

God grant me the serenity…………

– Lost and Tired

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Julie Costanten

The low levels may be the beginning of an explanation as to what is wrong with Gavin.

Antibodies are proteins made by the immune system to destroy foreign invaders. There are five major types of antibodies: immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin E (IgE) and immunglobulin D (IgD). An IgG antibody helps to battle bacterial and viral infections. Comprising up to 80% of the all of these essential proteins, it is the smallest, yet most abundant, human antibody. Found in all bodily fluids, IgG is the only antibody that can protect a fetus by passing through the mother's placenta.

A physician may order a quantitative immunoglobulin blood test to determine the exact level of each type of antibody if the results of either a total blood protein test or serum protein electrophoresis test — which can measure each type of protein in the blood — are abnormal. The doctor may also order a quantitative immunoglobulin test if the patient's symptoms suggest an autoimmune disease, allergies, certain blood cancers, or recurring infections. The test is also used to follow-up on the treatment for Helicobacter pylori (H. pylori) bacteria and to confirm a response to a vaccination already given, to ensure that the patient has achieved immunity to the disease.

Normal levels of the IgG antibody usually fall in the range of 565–1765 mg/dL (5.65–17.65 g/L). A higher than normal IgG antibody level can suggest an IgG monoclonal gammopathy, such as multiple myeloma — a cancer of the blood and bone marrow — or monoclonal gammopathy of undetermined significance (MGUS) — a benign, but sometimes pre-malignant condition. Elevated IgG antibody levels may also suggest the presence of a chronic infection with an illness such as AIDS or hepatitis. Multiple sclerosis (MS), a chronic neurological disease of the central nervous system, is another possible diagnosis when the IgG antibody level is higher than normal.

A lower than normal IgG antibody level may suggest some types of leukemia or nephrotic syndrome, which often results in kidney damage. Low levels of the IgG antibody can also be caused by Waldenstrom's macroglobulinemia, a rare blood cancer that is characterized by an overproduction of the IgM antibody and subsequent suppression of production of other types of antibodies, including IgG. In addition, some primary immunodeficiencies are defined by a low level or complete deficiency of IgG. These include: X-Linked Agammaglobulinemia (XLA), a congenital disease in which IgG, IgM and IgA antibody levels are all greatly reduced or non-existent; Common Variable Immunodeficiency (CVID), also known as hypogammaglobulinemia), a condition in which there is a reduction in the number of one or more of the main three antibodies (IgG, IgM or IgA); and Severe Combined Immunodeficiency, a genetic illness that usually presents with a reduction in all classes of antibodies.

Primary immunodeficiencies may be treated with Intraveneous Immunoglobulin (IVIG) therapy, which contains purified IgG antibodies collected from healthy donors. IVIG helps to protect immunodeficient patients by temporarily replacing the antibodies needed to fight infections. IVIG therapy is also used to treat some auto-immune and neurological diseases, such as dermatomyositis/polymyositis, idiopathic thrombocytopenic purpura(ITP), Guillain-Barre syndrome, and chronic inflammatory demyelinating polyneuropathy (CIDP).

Lizzeann

Thank you Vette & Tam! <3
My recent post Thank GOD!

Nan

Looks like he might be developing hives, and they can be a symptom of an autoimmune disorder. Another piece to the puzzle maybe? Poor kid (and poor parents!) I hope you guys get this figured out quickly.

Tam

He has a deficiency in his immune system, here are a couple of links that explain what IgG and IgM are about: http://emedicine.medscape.com/article/136897-overhttp://emedicine.medscape.com/article/137693-over

A compromised immune system could be the cause of a type of peripheral neuropathy they were concerned about (one possibility being be Guillain-Barré syndrome), if it is that they can treat it and recovery is good, it's just important to get the treatment started quickly.

Vette

Rob –
I am a medical transcriptionist. I transcribe for a clinic of Drs in North Carolina. I am going to email them right now and see what information they can give me on this subject for you. I will let you & Lizze know as soon as I hear back! Stay strong. Much love

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